Dušan Uhrín Group
Welcome to the Uhrín group at the School of Chemistry, University of Edinburgh. Our work focuses on developing new liquid-state NMR methods and their application to studies of carbohydrates, carbohydrate-protein interactions and complex mixtures like dissolved organic matter, soil and more pleasurable commodities such as Scotch whisky.
We are part of the Scottish NMR Users Group (SNUG) which brings together NMR research and facilities across Scotland. Visit the SNUG webpage to find out more.
C. L. Dickson, G. Peat, M. Rossetto, M. E. Halse and D. Uhrin
Chem. Commun., 2022, 58, 5534–5537.
We present a signal enhancement strategy for benchtop NMR that produces SNR increases on the order of 10 to 30 fold by collapsing the target resonance into an extremely narrow singlet. Importantly, the resultant signal is amenable to quantitative interpretation and therefore can be applied to analytical applications such as reaction monitoring.
A. J. R. Smith, R. York, D. Uhrín and N. G. A. Bell
Chem. Sci., 2022, 13, 3766–3774.
Although the number of natural fluorinated compounds is very small, fluorinated pharmaceuticals and agrochemicals are numerous. 19F NMR spectroscopy has a great potential for the structure elucidation of fluorinated organic molecules, starting with their production by chemical or chemoenzymatic reactions, through monitoring their structural integrity, to their biotic and abiotic transformation and ultimate degradation in the environment. Addressing limitations of the existing 19F NMR techniques, we have developed methodology that uses 19F as a powerful spectroscopic spy to study mixtures of fluorinated molecules. Here we illustrate the 19F-centred structure determination process and demonstrate its power by successfully elucidating the structures of chloramination disinfectant by-products of a single monofluorinated phenolic compound, which would have been impossible otherwise.